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Synthesis and x-ray study of novel azofurazan-annulated macrocyclic lactams

โœ Scribed by Aleksei B. Sheremetev; Nataliya S. Aleksandrova; Dmitrii E. Dmitriev; Boris B. Averkiev; Mikhail Yu. Antipin

Book ID
102343926
Publisher
Journal of Heterocyclic Chemistry
Year
2005
Tongue
English
Weight
93 KB
Volume
42
Category
Article
ISSN
0022-152X

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โœฆ Synopsis

Reaction of 1,4-di-(3-aminofurazan-4-oyl)piperazine 4 with dibromoisocyanurate (DBI) affords azofurazan-annulated macrocyclic lactam 7; the X-ray structure of the macrocycle 7 is reported. The synthesis was started with 3-aminofurazan-4-carboxylic acid 1. A one-pot method for preparation of the amino acid was elaborated from commercially available cyanoacetic ester. Amides of the acid have been prepared via the esterification and subsequent amination.

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