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Synthesis and tubulin-binding properties of new allocolchicinoids

✍ Scribed by François-Didier Boyer; Joëlle Dubois; Sylviane Thoret; Marie-Elise Tran Huu Dau; Issam Hanna


Book ID
103825800
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
823 KB
Volume
38
Category
Article
ISSN
0045-2068

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Colchicine Models: Synthesis and Binding
✍ Yoshikuni Itoh; Arnold Brossi; Ernest Hamel; Chii M. Lin 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 German ⚖ 769 KB

Synthesis of tetramethoxybiphenyl21 was accomplished from 4-phenylcyclohexane-1,3-dione 13 by aromatization to biphenyl 19 and reductive removal of the phenolic OH group as phenyltetrazolyl ether. Tetramethoxybiphenyls 34 and 40 were obtained from 4-phenylcyclohexenone 26 via ester 27. The tetrameth