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Cellular uptake and tubulin binding properties of four vinca alkaloids

✍ Scribed by William D. Singer; Richard H. Himes


Book ID
115782996
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
884 KB
Volume
43
Category
Article
ISSN
0006-2952

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The basis for the markedly altered intracellular binding of ['Hlvincristine in a multidrug-resistant variant (DC-3FNCRd-SL) of Chinese hamster lung cells [DC-3F) was investigated. Binding of [3Hlvincristine by protein in cytosol derived from each cell type exhibited a differing requirement for GTP i