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Synthesis, binding and cellular uptake properties of oligodeoxynucleotides containing cationic bicyclo-thymidine residues

✍ Scribed by Jory Lietard; Damian Ittig; Christian J. Leumann


Book ID
113495426
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
630 KB
Volume
19
Category
Article
ISSN
0968-0896

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The reactions of diacids with the bicyclophosphane 1 lead to podands 3a-f in which two dioxazaphosphocane moieties are linked by a more or less rigid spacer owing to the starting diacid. Macrocycles 4a-b are. obtained by cyclixation of podands 3a-b by way of Michaelis-Becker reaction. The formation