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Synthesis and binding to tubulin of colchicine spin probes

โœ Scribed by Sharma, Padam N.; Brossi, Arnold; Silverton, J. V.; Chignell, Colin F.


Book ID
126967325
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
673 KB
Volume
27
Category
Article
ISSN
0022-2623

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Colchicine Models: Synthesis and Binding
โœ Yoshikuni Itoh; Arnold Brossi; Ernest Hamel; Chii M. Lin ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 769 KB

Synthesis of tetramethoxybiphenyl21 was accomplished from 4-phenylcyclohexane-1,3-dione 13 by aromatization to biphenyl 19 and reductive removal of the phenolic OH group as phenyltetrazolyl ether. Tetramethoxybiphenyls 34 and 40 were obtained from 4-phenylcyclohexenone 26 via ester 27. The tetrameth