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Synthesis and transformations of d-glucuronic and l-iduronic acid glycals

✍ Scribed by Peter Schell; Hernan A Orgueira; Susanne Roehrig; Peter H Seeberger

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 92 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00607-4

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✦ Synopsis

D-Glucuronic acid glycals can be efficiently synthesized from diacetone glucose or tri-O-acetyl glycal and can be transformed into D-glucuronic acid donors and acceptors in high yields. Base catalyzed epimerization of D-glucuronic acid glycals provides access to the corresponding L-iduronic acid glycals. Both D-glucuronic and L-iduronic acid glycals were transformed into glycosylating agents for use in the synthesis of glycosaminoglycan oligosaccharides.

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