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Synthesis and the Keto-enol Equilibrium of 2-Acyl Lactams.

✍ Scribed by V. G. Nenajdenko; A. M. Gololobov; E. P. Zakurdaev; E. S. Balenkova


Publisher
John Wiley and Sons
Year
2004
Weight
120 KB
Volume
35
Category
Article
ISSN
0931-7597

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Ξ²-Lactam synthesis: Cyclization versus 1
✍ Jollie D Godfrey Jr.; Richard H Mueller; Derek J Von Langen πŸ“‚ Article πŸ“… 1986 πŸ› Elsevier Science 🌐 French βš– 218 KB

The cyclization of hydroxamate 1 unexpectedly afforded two isomeric @lactams 2 and 1. The mechanism for the formation of 2 has been shown by carbon-13 labeling to involve a novel 1,2-acyl migration-cyclization process.