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Synthesis and the biological evaluation of 2-benzenesulfonylalkyl-5-substituted-sulfanyl-[1,3,4]-oxadiazoles as potential anti-hepatitis B virus agents

โœ Scribed by Theresa May Chin Tan; Yu Chen; Kah Hoe Kong; Jing Bai; Yang Li; Seng Gee Lim; Thiam Hong Ang; Yulin Lam


Book ID
113457289
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
283 KB
Volume
71
Category
Article
ISSN
0166-3542

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## Abstract A series of novel 4__ฮฒ__โ€[(4โ€substituted)โ€1,2,3โ€triazolโ€1โ€yl]podophyllotoxin derivatives were synthesized by employing Cu^I^โ€catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HTโ€29, HCTโ€15, 502713, HOPโ€62, Aโ€549, MCFโ€