Design and synthesis of conformationally
โ
R. L. Magolda; W. Galbraith
๐
Article
๐
1989
๐
John Wiley and Sons
๐
English
โ 969 KB
The use of conformationally restricted phospholipids 1 and 2 has been employed to understand the conformational preference of phospholipase A2 (PLA2) for substrate phospholipids. Inhibition of porcine pancreatic PLA2 with 1 and 2 indicated a two-to fivefold preference for the distal isomer 2 over th