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Synthesis and Supramolecular Properties of Conformationally Restricted and Flexible Phospholipids

โœ Scribed by Vares, Lauri; Koulov, Atanas V.; Smith, Bradley D.


Book ID
126848313
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
120 KB
Volume
68
Category
Article
ISSN
0022-3263

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The use of conformationally restricted phospholipids 1 and 2 has been employed to understand the conformational preference of phospholipase A2 (PLA2) for substrate phospholipids. Inhibition of porcine pancreatic PLA2 with 1 and 2 indicated a two-to fivefold preference for the distal isomer 2 over th