Synthesis of a conformationally restrict
β
Luciano Barboni; Catia Lambertucci; Roberto Ballini; Giovanni Appendino; Ezio Bo
π
Article
π
1998
π
Elsevier Science
π
French
β 280 KB
A conformationally constrained analogue of the paclitaxel side-chain was synthesised in an enantioselective way from ethyl IH-indene-2-carboxylate. Coupling with 7-triethylsilylbaccatin III and deprotection afforded 2',2"-methylenepaclitaxel, a novel analogue of the natural product retaining antican