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Synthesis and Study of Naphthacenedione (TQ) as a Photosensitizer for One-Electron Oxidation of DNA

✍ Scribed by Roberts, Lezah W.; Schuster, Gary B.


Book ID
127374747
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
79 KB
Volume
6
Category
Article
ISSN
1523-7060

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DNA binding and photoinduced DNA cleaving properties of water-soluble naphthyridine derivative 1 were investigated. The photoinduced cleavage of DNA was studied by both PAGE and product analysis, indicating that the DNA cleavage proceeds via one\* electron oxidation pathway.