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p-Cyano substituted 5-benzoyldeoxyuridine as a novel electron-accepting nucleobase for one-electron oxidation of DNA

โœ Scribed by Kazuhiko Nakatani; Kazuhiko Fujisawa; Chikara Dohno; Takashi Nakamura; Isao Saito

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
209 KB
Volume
39
Category
Article
ISSN
0040-4039

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Water-soluble 2-amino-1,8-naphthyridine
Water-soluble 2-amino-1,8-naphthyridine as a novel DNA binding photosensitizer for one-electron oxidation of DNA
โœ Kazuhiko Nakatani; Shinsuke Sando; Kohzo Yoshida; Isao Saito ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 236 KB

DNA binding and photoinduced DNA cleaving properties of water-soluble naphthyridine derivative 1 were investigated. The photoinduced cleavage of DNA was studied by both PAGE and product analysis, indicating that the DNA cleavage proceeds via one\* electron oxidation pathway.