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Synthesis and study of a non macrocyclic FK506 derivative.

✍ Scribed by Simon J. Teague; Martin E. Cooper; David K. Donald; Mark Furber

Book ID
108476956
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
306 KB
Volume
4
Category
Article
ISSN
0960-894X

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Oxidation of the 22-hydrazone of ascomycin using manganese dioxide generates in situ the reactive 22-diazo intermediate, which decomposes to give ascomycin analogues with modified effector region. In dichloromethane several products are obtained, whereas in methanol a cyclopropane derivative is gene