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Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 3. 1 2-[ω-(4-Arylpiperazin-1-yl)alkyl]perhydropyrrolo- [1,2- c ]imidazoles and -perhydroimidazo[1,5- a ]pyridines: Study of the Influence of the Terminal Amide Fragment on 5-HT 1A Affinity/Selectivity

✍ Scribed by López-Rodríguez, María L.; Morcillo, M. José; Fernández, Esther; Porras, Esther; Murcia, Marta; Sanz, Antonio M.; Orensanz, Luis

Book ID
126980815
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
155 KB
Volume
40
Category
Article
ISSN
0022-2623

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Synthesis and Structure−Activity Relatio
Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 4. 1 1-[ω-(4-Arylpiperazin-1-yl)alkyl]-3-(diphenylmethylene)- 2,5-pyrrolidinediones and -3-(9 H -fluoren-9-ylidene)-2,5-pyrrolidinediones: Study of the Steric Requirements of the Terminal Amide Fragment on 5-HT 1A Affinity/Selectivity
✍ López-Rodríguez, María L.; Morcillo, M. José; Rovat, Tandú K.; Fernández, Esther 📂 Article 📅 1999 🏛 American Chemical Society 🌐 English ⚖ 303 KB
ChemInform Abstract: 1-[ω-(4-Arylpiperaz
ChemInform Abstract: 1-[ω-(4-Arylpiperazin-1-yl)alkyl] -3-diphenylmethylene-2,5-pyrrolidinediones as 5-HT1A Receptor Ligands: Study of the Steric Requirements of the Terminal Amide Fragment on 5-HT1A Affinity/Selectivity.
✍ M. L. LOPEZ-RODRIGUEZ; M. J. MORCILLO; T. K. ROVAT; E. FERNANDEZ; A. M. SANZ; L. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 40 KB 👁 1 views

## 1-[ω-(4-Arylpiperazin-1-yl)alkyl] -3-diphenylmethylene-2,5pyrrolidinediones as 5-HT 1A Receptor Ligands: Study of the Steric Requirements of the Terminal Amide Fragment on 5-HT 1A Affinity/Selectivity. -Two different methods are used to prepare the desired title compounds (IV) and (VII) which