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Synthesis and structure–activity relationships of 2-(substituted phenyl)-3-[3-(N,N-dimethylamino)propyl]-1,3-thiazolidin-4-ones acting as H1-histamine antagonists

✍ Scribed by M.Vittoria Diurno; Orazio Mazzoni; Gaetano Correale; Isabel Gomez Monterrey; Antonio Calignano; Giovanna La Rana; Adele Bolognese


Book ID
114019518
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
95 KB
Volume
54
Category
Article
ISSN
0014-827X

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Synthesis and Pharmacological Activity of 2-(Substituted Phenyl)-3-(2 or 3-((4-Substituted Phenyl-4-hydroxy)piperidino)ethyl or propyl)-1,3-thiazolidin-4-ones. -A new series of 1,3-thiazolidinone analogues of loperamide (cf. (IV), 10 examples) are synthesized and evaluated for their antidiarrheal a