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Synthesis and Structure−Activity Relationship of Small-Molecule Malonyl Coenzyme A Decarboxylase Inhibitors

✍ Scribed by Cheng, Jie-Fei; Chen, Mi; Wallace, David; Tith, Souvothy; Haramura, Masayuki; Liu, Bin; Mak, Chi Ching; Arrhenius, Thomas; Reily, Sean; Brown, Steven; Thorn, Vicki; Harmon, Charles; Barr, Rick; Dyck, Jason R. B.; Lopaschuk, Gary D.; Nadzan, Alex M.

Book ID
120379646
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
126 KB
Volume
49
Category
Article
ISSN
0022-2623

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A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elev