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Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities

✍ Scribed by Haifeng Tang; Yan Yan; Zhe Feng; Reynalda K. de Jesus; Lihu Yang; Dorothy A. Levorse; Karen A. Owens; Taro E. Akiyama; Raynald Bergeron; Gino A. Castriota; Thomas W. Doebber; Kenneth P. Ellsworth; Michael E. Lassman; Cai Li; Margaret S. Wu; Bei B. Zhang; Kevin T. Chapman; Sander G. Mills; Joel P. Berger; Alexander Pasternak

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 363 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.08.047

No coin nor oath required. For personal study only.

✦ Synopsis

A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elevated blood glucose in a murine model of type II diabetes.

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