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Synthesis and Structure−Activity Relationship of Aminobenzophenones. A Novel Class of p38 MAP Kinase Inhibitors with High Antiinflammatory Activity

✍ Scribed by Ottosen, Erik Rytter; Sørensen, Morten Dahl; Björkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise


Book ID
126289440
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
245 KB
Volume
46
Category
Article
ISSN
0022-2623

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✍ Robert M. Tynebor; Meng-Hsin Chen; Swaminathan R. Natarajan; Edward A. O’Neill; 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 705 KB

The development and synthesis of potent p38α MAP kinase inhibitors containing a pyridazinone platform is described. Evolution of the p38α selective pyridopyridazin-6-one series from the p38α/β dual inhibitor 2H-quinolizin-2-one series will be discussed in full detail.