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Synthesis and structure–activity relationship of a novel class of 15-membered macrolide antibiotics known as ‘11a-azalides’

✍ Scribed by Tomohiro Sugimoto; Tetsuya Tanikawa; Keiko Suzuki; Yukiko Yamasaki

Book ID: 119203653
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 970 KB
Volume: 20
Category: Article
ISSN: 0968-0896
DOI: 10.1016/j.bmc.2012.08.007

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## Abstract Based on a novel lead compound 4‐methylpiperazine‐1‐carbodithioic acid 3‐cyano‐3,3‐diphenylpropyl ester **1**, the systematic structural modification was carried out. All the synthesized compounds were evaluated for their __in‐vitro__ anticancer activities on four to six different cell