Synthesis and structure of substituted 3,4-dihydropyridin-2-ones
✍ Scribed by A. A. Krauze; É. É. Liepin'sh; Z. A. Kalme; Yu. É. Pelcher; G. Ya. Dubur
- Book ID
- 112348578
- Publisher
- Springer US
- Year
- 1984
- Tongue
- English
- Weight
- 405 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0009-3122
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📜 SIMILAR VOLUMES
Marazano et al. reported the asymmetric cycloaddition of 2-unsubstituted 1,2-dihydropyridines which are N-substituted with a chiral auxiliary [7]. Shono et al. published an enantioselective synthesis of methyl 1,2-dihydropyridine-2-carboxylate from Llysine [8].
## Abstract magnified image Small libraries of 3,5‐unsubstituted 4‐substituted‐6‐aryl‐3,4‐dihydropyridin‐2(1__H__)‐ones derivatives were synthesized from the condensation‐products of aldehydes with Meldrum's acid, aromatic ketones and ammonium acetate using acetic acid as energy transferring‐agent
In a short sequence, 5-vinyloxazolidin-2-ones were converted into the 3,6-disubstituted 3,6-dihydropyridin-2-ones via Pd-catalysed carbonylation and enolate alkylation with high diastereoselectivity. Alkylation of 6-substituted N-methylpyridin-2ones gives stereoselectively the 3,6-anti diastereoisom