An efficient microwave-assisted synthesis of 3,5-unsubstituted 4-substituted-6-aryl-3,4-dihydropyridin-2(1H)-ones derivatives

✍ Scribed by Shujiang Tu; Xiaotong Zhu; Feng Shi; Jinpeng Zhang; Yan Zhang

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2007
• Tongue: English
• Weight: 366 KB
• Volume: 44
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570440414

✦ Synopsis

Abstract

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Small libraries of 3,5‐unsubstituted 4‐substituted‐6‐aryl‐3,4‐dihydropyridin‐2(1__H__)‐ones derivatives were synthesized from the condensation‐products of aldehydes with Meldrum's acid, aromatic ketones and ammonium acetate using acetic acid as energy transferring‐agent under microwave irradiation without catalyst. This method has the advantages of excellent yields (65‐90%), short reaction time (5‐10 min) and being environmentally friendly. It aimed to provide new series of potential biologically active compounds for biomedical screening.