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Synthesis and structure of dihydro-1,2,4-triazin-6(1H) ones

โœ Scribed by Alfredo Camparini; Angela Maria Celli; Fabio Ponticelli; Piero Tedeschi


Book ID
112125453
Publisher
Journal of Heterocyclic Chemistry
Year
1978
Tongue
English
Weight
279 KB
Volume
15
Category
Article
ISSN
0022-152X

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A new and easy protocol for the formation of substituted 4,5-dihydro-1,2,4-triazin-6(1H)-ones was developed on solid support. The heterocyclic compounds were formed by nucleophilic reaction of hydrazine on thioamide esters. As cyclization was concomitant with cleavage from the support, substituted 4