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Synthesis and structure of 6-substituted 9-(2-ethoxy-1,3-dioxan-5-yl)purines

✍ Scribed by A. F. Mishnev; Ya. Ya. Bleidelis; É. É. Liepin'sh; N. P. Ramzaeva; I. N. Goncharova

Book ID
112327731
Publisher
Springer US
Year
1979
Tongue
English
Weight
602 KB
Volume
15
Category
Article
ISSN
0009-3122

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✍ Dae-Kee Kim; Young-Woo Kim; Namkyu Lee 📂 Article 📅 2001 🏛 Journal of Heterocyclic Chemistry 🌐 English ⚖ 108 KB

## Abstract Stereoselective synthesis of 5‐[2‐(guanin‐9‐yl)‐ and 5‐[2‐(2‐aminopurin‐9‐yl)ethyl]‐2‐D‐ribo‐(1′,2′,3′,4′‐tetrahydroxybutyl)‐1,3‐dioxane, 2‐5, as potential prodrugs of penciclovir, has been accomplished in six steps from readily available 2,3,4,5‐tetra‐__O__‐acetyl‐__aldehydo__‐D‐ribose