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Synthesis and Structural and Functional Evaluation of a Protein Modified with a β-Turn Mimic

✍ Scribed by Jean, Fabienne; Buisine, Eric; Melnyk, Oleg; Drobecq, Hervé; Odaert, Benoît; Hugues, Michel; Lippens, Guy; Tartar, André

Book ID
126144925
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
257 KB
Volume
120
Category
Article
ISSN
0002-7863

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Dichloropyrazinone 3 was converted into a conformationally restricted dipeptide analogue 8 by means of a Diels-Alder strategy. The b-turn characteristics of molecule 8 were examined by molecular modeling and NMR spectroscopy.