Synthesis and Stereochemistry of 11,11a-Dihydro Derivatives of (4 S )-2,4-Dimethyl-2,4-dihydro-1 H - pyrazino[2,1- b ]quinazoline-3,6-diones. A New Transannular Rearrangement Proposal
✍ Scribed by Martín-Santamaría, Sonsoles; Espada, Modesta; Avendaño, Carmen
- Book ID
- 127077516
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 55 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Abstmctz Dialkylation of the title compound occurs regioselectively at C-l. Addition of N,N'-diiethyl-NJ'-propylene urea (DMFV) permits the one-pot synthesis of I,l-dialkylation products in good yields. The asymmetric induction of the stereogenic C-4 center directs the first and the second alkylatio
The enamine character of the CH2-C(lla)=N(ll) fragment in the title compounds was studied. Congxatmds I gave l-dimethylaminomethylene products $ after Vilsmeier reaction. The l-formyl derivatives, obtained by alkaline hydrolysis of 5, were isolated as enol tautome~s and were vea'y unstable in acid m