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Synthesis and single crystal X-ray analysis of two griseofulvin metabolites

✍ Scribed by Mads H. Rønnest; Pernille Harris; Charlotte H. Gotfredsen; Thomas O. Larsen; Mads H. Clausen

Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
411 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

The two phenols, 6-O-desmethyl griseofulvin and 4-O-desmethyl griseofulvin are metabolites of the antifungal drug griseofulvin. Herein, we present an improved synthesis of the 6-phenol derivative, and an unequivocal proof of both structures by single-crystal X-ray analysis.

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