Synthesis and reactivity of diethyl phosphonomethyltriflate

✍ Scribed by Dennis P. Phillion; Steven S. Andrew

• Book ID: 104218372
• Publisher: Elsevier Science
• Year: 1986
• Tongue: French
• Weight: 218 KB
• Volume: 27
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)84289-6

✦ Synopsis

Diethyl phosphonomethyltriflate, prepared from diethyl hydroxymethylphosphonate, readily reacts in good to excellent yields with a variety of oxygen and nitrogen nucleophiles.

Currently, no mild method exists for effecting displacement reactions on the a-carbon of phosphonates. Such a reaction would be quite