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Synthesis and reactions of “biginelli-compounds”. Part I
✍ Scribed by Christian Oliver Kappe; Peter Roschger
- Book ID
- 112129155
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1989
- Tongue
- English
- Weight
- 731 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-152X
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📜 SIMILAR VOLUMES
Synthesis and Reactions of Biginelli Compounds. Part 12. Polyphosphate Ester Mediated Synthesis of Dihydropyrimidines. Improved Conditions for the Biginelli Reaction. -Improved conditions for the one-pot condensation of aldehydes, ureas, and acetoacetates are reported. Addition of catalytic amounts
An efficient and general liquid-phase synthesis of Biginelli compounds has been developed. Polyethylene glycol (PEG) bound acetoacetate reacted with urea and aldehydes under reflux or solvent-free microwave irradiation conditions to afford PEG-supported 3,4-dihydropyrimidin-2(1H)-ones. The desired 3