β Scribed by C. O. KAPPE; S. F. FALSONE
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Synthesis and Reactions of Biginelli Compounds. Part 12. Polyphosphate Ester Mediated Synthesis of Dihydropyrimidines. Improved Conditions for the Biginelli Reaction.
-Improved conditions for the one-pot condensation of aldehydes, ureas, and acetoacetates are reported. Addition of catalytic amounts of polyphosphate ester provides the dihydropyrimidines in high yields compared to low or moderate yield under Biginelli conditions. Intermediate (XVI), previously assigned to be (XVII), can be isolated as the sole product in diastereomerically pure form. -(KAPPE,
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Synthesis and Reactions of Biginelli Compounds. Part 10. Synthesis and Aromatization of Dihydropyrimidines Structurally Related to Calcium Channel Modulators of the Nifedipine-Type. -By employing the "Hideg-modification" of the Biginelli reaction a number of 1,4-dihydropyrimidines (IV) (8 examples)