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Soluble polymer-supported synthesis of Biginelli compounds

✍ Scribed by Min Xia; Yan-Guang Wang

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
94 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

An efficient and general liquid-phase synthesis of Biginelli compounds has been developed. Polyethylene glycol (PEG) bound acetoacetate reacted with urea and aldehydes under reflux or solvent-free microwave irradiation conditions to afford PEG-supported 3,4-dihydropyrimidin-2(1H)-ones. The desired 3,4-dihydropyrimidin-2(1H)-ones were cleaved from the polymer support under mild conditions in high yields and high purity.

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## Abstract Poly(ethylene glycol) (PEG)‐supported dendrimers have been synthesized using 2,4,6‐trichloro‐1,3,5‐triazine (TCT) as dendrons and tris(hydroxymethyl)aminomethane as linkers with high loading capacity, excellent solubility and thermal stability by divergent method. The new synthesized PE