Synthesis and Reactions of 4H-3,1-Benzothiazines. -The target compound of this study is the pyrrolo[1,2-a]indole skeleton which is the essential ring system of the active antitumor mitomycins. Although the synthesis of this ring system fails, a number of novel heterocycles is obtained affording new
Synthesis and reactions of 4H-3,1-benzothiazines
β Scribed by S. I. El-Desoky; E. M. Kandeel; A. H. Abd-El-Rahman; R. R. Schmidt
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1999
- Tongue
- English
- Weight
- 516 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0022-152X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The reaction of 3-substituted-4-hydroxyroxy-2H-1,2-be~othiazine 1,l-dioxides with aryl isocyanate under different equivalents of strong base NaH was studied. Seventeen of new derivatives were obtained whose structures were characterized by ' H NMR, IR, MS, elementary analysis and FeCls test. ## Key
## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract The title compounds (V), which cannot be obtained by direct oxidation of (I), are prepared using the reversible formation of a dichloroβΞ²βlactam moiety as novel protecting group.
## Treatment of the hydrochloride salts of 4-chloro-5-(2halomethylaryl-imino)-5H-l,2,3-dithiazoles (2) with sodium cyanoborohydride in THF at room temperature gave 2-cyan0-4H-3,l -benzothiazines ( I ) in good to moderate yields. 2-Cyano-4H-3,l -benzoxazines (4) were obtained in good to moderate yiel
## Abstract New compounds of 2βarylβ4__H__β3,1βbenzothiazine set were synthesized and tested for their antiproliferative activity as part of our research in the antitumor field. The title compounds were obtained by the reaction of arylβmodified sulfinylbis((2,4βdihydroxyphenyl)methanethione) with 2