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Synthesis and reactions of 4H-3,1-benzothiazines

✍ Scribed by S. I. El-Desoky; E. M. Kandeel; A. H. Abd-El-Rahman; R. R. Schmidt


Publisher
Journal of Heterocyclic Chemistry
Year
1999
Tongue
English
Weight
516 KB
Volume
36
Category
Article
ISSN
0022-152X

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Synthesis and Reactions of 4H-3,1-Benzothiazines. -The target compound of this study is the pyrrolo[1,2-a]indole skeleton which is the essential ring system of the active antitumor mitomycins. Although the synthesis of this ring system fails, a number of novel heterocycles is obtained affording new

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The reaction of 3-substituted-4-hydroxyroxy-2H-1,2-be~othiazine 1,l-dioxides with aryl isocyanate under different equivalents of strong base NaH was studied. Seventeen of new derivatives were obtained whose structures were characterized by ' H NMR, IR, MS, elementary analysis and FeCls test. ## Key

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## Abstract New compounds of 2‐aryl‐4__H__‐3,1‐benzothiazine set were synthesized and tested for their antiproliferative activity as part of our research in the antitumor field. The title compounds were obtained by the reaction of aryl‐modified sulfinylbis((2,4‐dihydroxyphenyl)methanethione) with 2