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Synthesis and Properties of the Oligonucleotide N3′ →P5′ Phosphoramidates

✍ Scribed by Gryaznov, Sergei M.

Book ID
120976151
Publisher
Taylor and Francis Group
Year
1997
Tongue
English
Weight
441 KB
Volume
16
Category
Article
ISSN
0732-8311

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✍ Ronald G Schultz; Sergei M Gryaznov 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 150 KB

Oligonucleotide analogues with a novel sugar-phosphate backbone containing 2 -arabino-fluoronucleosides and phosphoramidate 3 -NHP(O)(O -)O-5 internucleoside linkages were prepared. These compounds have demonstrated high binding affinity to complementary nucleic acids as well as greater acid stabili