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Oligonucleotide N3′→P5′ thiophosphoramidates: synthesis and properties

✍ Scribed by Krisztina Pongracz; Sergei Gryaznov


Book ID
104262363
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
221 KB
Volume
40
Category
Article
ISSN
0040-4039

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arabino-Fluorooligonucleotide N3′→P5′ ph
✍ Ronald G Schultz; Sergei M Gryaznov 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 150 KB

Oligonucleotide analogues with a novel sugar-phosphate backbone containing 2 -arabino-fluoronucleosides and phosphoramidate 3 -NHP(O)(O -)O-5 internucleoside linkages were prepared. These compounds have demonstrated high binding affinity to complementary nucleic acids as well as greater acid stabili