Synthesis and properties of novel amino acid linked phosphoryl nitrogen mustard derivatives

✍ Scribed by Ru-Yu Chen; Hui-Lin Wang; Jia Zhou

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 390 KB
• Volume: 5
• Category: Article
• ISSN: 1042-7163
• DOI: 10.1002/hc.520050513

✦ Synopsis

In order to look foi-novel antitumor drugs and virucides u-itli high activitx and loiv toxicity, a series of amino acid linked phosphor$ nitrogen mustard derivatives have been synthesized. The structures of all compounds prepared were confirmed by ' H N M R , 31P NMR, IR, M S spectroscopy, and elemental analvses. I n the case of dl-a-amino acid derivatives, the presence of multiple chiral centers in the target products leads to the generation of diastereoisomers, which can be detected by spectroscopic and analytical (TLC) methods. Preliminary bioassays indicate that some of compounds 5 have high inhibitory activities against some tumor cells and tobacco mosaic virus (TMV). In addition, some of them display certain herbicidal activities and significant fungicidal activities against wheat leaf rust.