Synthesis and properties of morpholino chimeric oligonucleotides
✍ Scribed by Nan Zhang; Chunyan Tan; Puqin Cai; Yuyang Jiang; Peizhuo Zhang; Yufen Zhao
- Book ID
- 108284952
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 128 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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## Abstract A solid phase technique for the preparation of antisense oligodeoxynucleotides (ODNs) is described featuring 5′‐end conjugated 4‐[(1,4,8,11‐tetraazacyclotet‐radec‐1‐yl)‐methyl]benzoic acid (CPTA). Using Fmoc‐protected CPTA–C6 amidite, CPTA was conjugated to ODNs at the end of an automat