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Synthesis and Properties of Chiral Open-Ring Acyclic Nucleoside Bisphosphonates

✍ Scribed by Petra Doláková; Martin Dračínský; Antonín Holý

Book ID
113457528
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
67 KB
Volume
74
Category
Article
ISSN
0166-3542

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📜 SIMILAR VOLUMES

A novel approach to unsaturated acyclic
A novel approach to unsaturated acyclic nucleoside analogues and the first synthesis of d4T by ring closure metathesis
✍ David Ewing; Virginie Glaçon; Grahame Mackenzie; Denis Postel; Christophe Len 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 55 KB

enyloxy]prop-2-enyl}cytosine have been prepared in good yield from uridine and 5-methyluridine by periodate cleavage followed by a double Wittig reaction which introduces two vinyl groups. The thymine derivative underwent ring closure metathesis to give a novel synthesis of d4T.