✦ LIBER ✦
A novel approach to unsaturated acyclic nucleoside analogues and the first synthesis of d4T by ring closure metathesis
✍ Scribed by David Ewing; Virginie Glaçon; Grahame Mackenzie; Denis Postel; Christophe Len
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 55 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
enyloxy]prop-2-enyl}cytosine have been prepared in good yield from uridine and 5-methyluridine by periodate cleavage followed by a double Wittig reaction which introduces two vinyl groups. The thymine derivative underwent ring closure metathesis to give a novel synthesis of d4T.