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Synthesis and properties of ApU analogs containing 2'-halo-2'-deoxyadenosines. Effects of 2' substituents on oligonucleotide conformation

✍ Scribed by Uesugi, Seiichi; Kaneyasu, Toshinori; Ikehara, Morio

Book ID: 126123553
Publisher: American Chemical Society
Year: 1982
Tongue: English
Weight: 946 KB
Volume: 21
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi00266a022

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## Abstract Cyclohexyl nucleosides with an adenine and uracil base have been synthesized from 2‐azidocyclohexane‐1,5‐diol. The obtained racemic nucleosides were resolved using (__R__)‐__O__‐methylmandelic acid. Short oligonucleotides were synthesized using phorphoramidite chemistry. However, these