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Synthesis and properties of 4-substituted 1,5-naphthyridines and their N-oxides

✍ Scribed by R. M. Titkova; A. S. Elina; E. A. Trifonova; I. V. Persianova; N. P. Solov'eva; E. M. Peresleni; T. A. Gus'kova; Yu. N. Sheinker

Book ID: 112346166
Publisher: Springer US
Year: 1981
Tongue: English
Weight: 700 KB
Volume: 17
Category: Article
ISSN: 0009-3122
DOI: 10.1007/bf00503484

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## Abstract Ethyl 1‐ethyl‐7‐methyl‐4‐oxo‐1,4‐dihydro[1,8]naphthyridine‐3‐carboxylate (**1**), precursor of nalidixic acid, has been converted in two steps through ([1,8]naphthyridin‐3‐yl)carbonylguanidine derivatives into substituted pyrimido[4,5‐__b__] and [5,4‐__c__][1,8]naphthyridines.