Synthesis and properties of 2-substituted 1-aryl-7,8-dihydro-6H-pyrimido[4,5-b]pyrindine-4-ones
✍ Scribed by R. N. Galeeva; M. Yu. Gavrilov; E. V. Feshina; M. E. Kon'shin
- Publisher
- Springer US
- Year
- 1997
- Tongue
- English
- Weight
- 213 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0009-3122
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## Abstract A new method was developed for the synthesis of 6,7‐dihydro‐5__H__‐pyrimido[4,5‐__e__][1,4]diazepin‐8(9__H__)‐one derivatives. The key to construct the pyrimido[4,5‐__e__][1,4]diazepine core is the intramolecular amidation of __N__‐((4‐amino‐6‐chloropyrimidin‐5‐yl)methyl)‐substituted am
## Abstract The reaction of 1‐aryl‐3‐(dimethylamino)‐1‐propanones 1 with one equivalent of 4,5‐diamino‐1__H__‐pyrimidin‐6‐ones 2, in acidic medium, leads to the formation of 4‐aryl‐2,3,6,7‐tetrahydro‐1__H__‐pyrimido[4,5‐__b__]‐[1,4]diazepin‐6‐ones 3. The structure elucidation of the products is bas