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Synthesis and pharmacological studies of new pyrazole analogues of podophyllotoxin

โœ Scribed by Umesha, B.; Basavaraju, Y. B.


Book ID
127066675
Publisher
SP MAIK Nauka/Interperiodica
Year
2014
Tongue
English
Weight
997 KB
Volume
40
Category
Article
ISSN
1068-1620

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Synthesis and antitumor activity of podo
โœ Kiyoshi Tomioka; Yoshihiro Kubota; Kenji Koga ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 157 KB

## Podophyllotoxin aza-analogue 7 (3 RI =H, Rz=Me, H) was designed and synthesized by a highly stereoselective condensation reaction of a cyclic urethane 5 with 3,4,5-trimethoxybenzaldehyde 6 and was found to show a promising in vitro and in vivo antitumor activity. Podophyllotoxin