Synthesis and antitumor activity of podo
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Kiyoshi Tomioka; Yoshihiro Kubota; Kenji Koga
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Article
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1989
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Elsevier Science
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French
โ 157 KB
## Podophyllotoxin aza-analogue 7 (3 RI =H, Rz=Me, H) was designed and synthesized by a highly stereoselective condensation reaction of a cyclic urethane 5 with 3,4,5-trimethoxybenzaldehyde 6 and was found to show a promising in vitro and in vivo antitumor activity. Podophyllotoxin