Synthesis and pharmacological properties of 1,2,3-substituted 1,2,3,4-tetrahydro-β-carbolines
✍ Scribed by S. A. Pogosyan; L. A. Matevosyan; A. S. Melik-Ogandzhanyan; R. R. Safrazbekyan; E. M. Arzanunts; I. S. Sarkisyan; R. G. Paronikyan; N. E. Akopyan
- Book ID
- 112399896
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 330 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0091-150X
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## Abstract Die Beziehungen zwischen Struktur und neuropsychotroper Wirkung bei 6 neuen 1,2,3,4‐Tetrahydro‐β‐carbolinen werden untersucht. Die aktivste Verbindung 4b hat ein pharmakologisches Profil, das dem Chlorpromazin ähnelt. Keine der Substanzen hat dopaminerge Eigenschaften.
The stereospecific synthesis of trans-1,3-disubstituted-1,2,3,4\_tetrahydro $-carbolines has been accomplished in good yield by a two step sequence which involves Pi&et-Spengler condensation of Nb-benzyltryptophan methyl: ester with aldehydes, followed by removal of the 2-benzyl moiety from the corr