Synthesis and Pharmacological Evaluation of SNC80 Analogues with a Bridged Piperazine Ring

✍ Scribed by Ralph Holl; Bettina Jung; Dirk Schepmann; Hans-Ulrich Humpf; Renate Grünert; Patrick J. Bednarski; Werner Englberger; Bernhard Wünsch

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 375 KB
• Volume: 4
• Category: Article
• ISSN: 1860-7179
• DOI: 10.1002/cmdc.200900358

✦ Synopsis

Pharmacological Evaluation

Receptor binding studies

The affinity of the bridged piperazine derivatives 9, 12, 15, 19, 20, 24, 25, and their enantiomers toward d, m, and k receptors was investigated in receptor binding studies using tritium-Scheme 3. Reagents and conditions: a) TFA, reflux, 16 h, 66 %; b) 18, Bu 4 NI, K 2 CO 3 , CH 3 CN, reflux, 16 h, 42 % (19), 40 % (20).