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Synthesis, Pharmacological Properties and SAR of New 1,4-Disubstituted Piperazine Derivatives with Hypnotic-Sedative Activity.

✍ Scribed by Z. Chilmonczyk; M. Mazgajska; E. Chojnacka-Wojcik; E. Tatarczynska; A. Klodzinska; M. Ulman


Publisher
John Wiley and Sons
Year
2004
Weight
10 KB
Volume
35
Category
Article
ISSN
0931-7597

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## Abstract Reaction of 4‐phenyl‐4__H__‐1,2,4‐triazole‐3‐thione with ethyl bromoacetate has led to the formation of ethyl [(4‐phenyl‐4__H__‐1,2,4‐triazol‐3‐yl)sulfanyl]acetate **1**, the structure of which was confirmed by X‐ray analysis. In the next reaction with 80% hydrazide hydrate, appropriate