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Synthesis and Pharmacological Evaluation of Huprine−Tacrine Heterodimers: Subnanomolar Dual Binding Site Acetylcholinesterase Inhibitors

✍ Scribed by Camps, Pelayo; Formosa, Xavier; Muñoz-Torrero, Diego; Petrignet, Julien; Badia, Albert; Clos, M. Victòria


Book ID
115478108
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
86 KB
Volume
48
Category
Article
ISSN
0022-2623

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✍ Isabel Dorronsoro; Diana Alonso; Ana Castro; Maria del Monte; Esther García-Palo 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 125 KB 👁 2 views

## Abstract The synthesis of tacrine‐thiadiazolidinone hybrids is described. These compounds are designed as dual acetylcholinesterase inhibitors binding simultaneously to the peripheral and catalytic sites of the enzyme. All tested compounds exhibit significant AChE inhibitory activity. Competitio