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Design, synthesis and biological evaluation of organophosphorous-homodimers as dual binding site acetylcholinesterase inhibitors

✍ Scribed by Ruliang Xie; Qianfei Zhao; Tao Zhang; Jing Fang; Xiangdong Mei; Jun Ning; Yun Tang


Book ID
119203714
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
277 KB
Volume
21
Category
Article
ISSN
0968-0896

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## Abstract The synthesis of tacrine‐thiadiazolidinone hybrids is described. These compounds are designed as dual acetylcholinesterase inhibitors binding simultaneously to the peripheral and catalytic sites of the enzyme. All tested compounds exhibit significant AChE inhibitory activity. Competitio