Synthesis and pharmacological activity of acetylenic piperidinediols
โ Scribed by A. S. Zakharevskii; A. M. Zvonok; A. P. Lugovskii; L. A. Melentovich; L. S. Stanishevskii; E. V. Yushkevich
- Book ID
- 112400262
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 346 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0091-150X
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๐ SIMILAR VOLUMES
A series of acetylenic thiophene derivatives have been synthesized via Pd-catalyzed coupling reaction of 2-(butyltelluro)thiophene with a variety of terminal alkynes. These compounds showed good anti-inflammatory activity in the carrageenininduced paw edema assay on rats.
Acetylenic derivatives of quinazolinones and quinazolinediones were synthesized and evaluated for their anticonvulsant activity. Most compounds displayed seizure-antagonizing activity in the maximal electroschock test (MES test) in most cases associated with little or no acute neurotoxicity determin