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Synthesis and NMR spectroscopic studies of optically active derivatives of γ-aminobutenoic acids and 2-amino-pyrrolin-4-ones

✍ Scribed by Margarita Petroliagi; Olga Igglessi-Markopoulou

Publisher
Journal of Heterocyclic Chemistry
Year
2001
Tongue
English
Weight
53 KB
Volume
38
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

An efficient method for the preparation of optically active derivatives of γ‐amino‐butenoic acids and their cyclic derivatives, 2‐amino‐pyrrolin‐4‐ones, from α‐amino acids is described. Partial racemization accompanies the formation of initial unsaturated γ‐amino‐β‐hydroxy esters 5–8, as determined by chiral HPLC.

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