✦ LIBER ✦

Synthesis and spectroscopic studies of optically active n-acetyl butenoates and n-acetyl-2-alkyl-pyrrolin-4-ones

✍ Scribed by Efstathios Gavrielatos; Giorgos Athanasellis; Olga Igglessi-Markopoulou

Publisher: Journal of Heterocyclic Chemistry
Year: 2002
Tongue: English
Weight: 43 KB
Volume: 39
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570390127

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✦ Synopsis

Abstract

The synthesis of a series of optically active N‐acetyl butenoates 3–5 is described using a facile methodology. These butenoates undergo cyclization to the corresponding N‐acetyl‐2‐alkyl‐pyrrolin‐4‐ones 6,7 retaining their stereochemical integrity. The structure of the newly synthesized compounds has been elucidated through ^1^H‐^13^C NMR, IR spectroscopy and their enantiomeric excesses have been measured by chiral HPLC analysis.

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